Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure
نویسندگان
چکیده
منابع مشابه
OECD GUIDELINE FOR THE TESTING OF CHEMICALS Acute Oral Toxicity: Up-and-Down Procedure
1. The proposal for this guideline was submitted by the United States. The concept of the upand-down testing approach was first described by Dixon and Mood (1)(2). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (3). There exist several variations of the up-and-down experimental design for estimating an LD50. This guideline is b...
متن کاملUP AND DOWN PROCEDURE: IS THERE NEED FOR FURTHER COMPUTER SIMULATIONS AND IN VIVO VALIDATION? BACKGROUND Acute Oral Toxicity Testing The acute oral toxicity test seeks to estimate the dose at which 50% of the organisms in adefined
The acute oral toxicity test seeks to estimate the dose at which 50% of the organisms in adefined population will die (LD50) after exposure to a test material. The statistical basis for the classicstudy design was first described in the 1920s and remained in use until current times. In this test,groups of animals were administered varying doses of test material, and a dosed animal either lived ...
متن کاملAcute and Subacute Toxicology in Evaluation of Pesticide Hazard to Avian Wildlife: Appx P3 - The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals
Single-dose acute oral and short-term subacute dietary toxicity tests with captive birds provide critical information on the potential hazard of pesticides to wild populations. The two tests have similar experimental designs and both generate a lethality curve and estimation of its midpoint, the median lethal dosage (LD50) or concentration (LC50). Although LD50s and LC50s are widely used to cha...
متن کاملAcute oral toxicity.
The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. The LD50 value, defined as the statistically derived dose that, wh...
متن کاملAcute and sub-acute oral toxicity of ethanol extract of Cassia fistula fruit in male rats
Objective: The plantCassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of...
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ژورنال
عنوان ژورنال: OECD guidelines for the testing of chemicals
سال: 2022
ISSN: ['2074-5753']
DOI: https://doi.org/10.1787/9789264071049-en